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Menopause and cognitive effects of oestradiol

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❓Did you know: Women are at increased risk of Alzheimer’s disease (being 68% of cases), influenced by the loss of oestrogen in menopause.

Oestradiol improves cognition and lowers risk of AD in post-menopausal women by at least 34%, with beneficial results dominating with use of topical oestradiol.[1-4]

The many benefits of oestradiol [5]

Oestradial helps memory and cognition:

  • Neuroprotective and modulating

    • ↑ neurogenesis, network activity and synaptic transmission

  • Master regulator of mitochondria

    • ↑ ATP/energy production

  • ↓ inflammatory response to beta-amyloid

    • ↓ beta-amyloid levels and toxicity, and ↑ clearance

Oestradial helps vascular health (which contributes to 40% of AD cases):

  • Enhances vascular health and ↓ cardiovascular death

    • ↓ oxidation of LDL cholesterol

    • ↓ plaque formation

    • ↑ vasodilation (stimulates nitric oxide)

    • Improves vascular elasticity

    • ↓ BP

Maximum cardioprotective effects when oestradiol is initiated at first symptoms of menopause and within first 10 years after menopause.[4]

Have a look at the evidence. Perhaps bioidentical HRT is part of the puzzle for many menopausal women.


  1. Wharton W, et al. Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease. Am J Transl Res 2009;1(2):131-147.

  2. Rahman A, et al. Sex and gender driven modifiers of Alzheimer's: The role for estrogenic control across age, race, medical, and lifestyle risks. Front Aging Neurosci 2019;11:315.

  3. Hogervorst E, et al. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst Rev 2002;(3):CD003122.

  4. Mikkola TS, et al. Lower death risk for vascular dementia than for Alzheimer’s disease with postmenopausal hormone therapy users. J Clinical Endocrin Metabol 2017;102(3):870-877.

  5. Nilsen J, et al. Estradiol in vivo regulation of brain mitochondrial proteome. J Neurosci 2007;27(51):14069-14077.


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